“Amanda Paulovich, M.D., Ph.D.
Professor and Aven Foundation Endowed Chair
Director, CLIA Targeted Proteomic Laboratory
Translational Science and Therapeutics Division
Fred Hutchinson Cancer Center
Professor, Department of Medicine / Division of Hematology & Oncology
University of Washington School of Medicine
Dr. Paulovich is Professor and Aven Foundation Endowed Chair at the Fred Hutchinson Cancer Center and Professor at the University of Washington School of Medicine
in Seattle. As a medical oncologist, Dr. Paulovich was struck by the paucity of effective diagnostics for measuring clinically relevant phenotypes in her patients, and the limitations that this put on her ability to practice “personalized oncology.” One patient’s tumor would melt away with standard of care therapy, whereas another patient with what appeared to be the same tumor would nonetheless experience disease progression on the same therapy. One patient would experience life-threatening toxicity, whereas another patient receiving the same therapy would not develop side effects.
Out of these experiences, she became passionate about ushering in a new approach to medical decision making, no longer based on single-gene or single-protein diagnostics, but rather combining multimodal data (e.g., molecular, demographic, clinical) to arm clinicians with tools for early and effective interventions to promote wellness and enable precision medicine.
Over the past 21 years, Dr. Paulovich’s interdisciplinary laboratory at the Fred Hutchinson Cancer Center has focused on proteogenomic approaches to understanding cancer biology and on laying the groundwork for the clinical translation of NextGen diagnostics to support precision medicine.
Dr. Paulovich completed a residency in Internal Medicine at Massachusetts General Hospital and a fellowship in Oncology at Dana-Farber Cancer Institute. She completed her Ph.D. training in genetics with Dr. Lee Hartwell at the University of Washington and postdoctoral training in genomics at the Massachusetts Institute of Technology with Dr. Eric Lander. She completed her M.D. at the University of Washington, and her B.S. at Carnegie Mellon University. ¬
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Director, Clinical Research Proteomics Platform
Brotman Baty Institute for Precision Medicine
Professor, Department of Medicine, Division of Medical Oncology
University of Washington School of Medicine
Associate Faculty Member, Molecular and Cellular Biology Program
University of Washington
